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Effect of iodide on total antioxidant status of human serum
Author(s) -
Winkler Rudolf,
Griebenow Sirid,
Wonisch Willibald
Publication year - 2000
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/(sici)1099-0844(200006)18:2<143::aid-cbf857>3.0.co;2-#
Subject(s) - antioxidant , iodide , antioxidant capacity , chemistry , zoology , food science , biochemistry , biology , inorganic chemistry
Free radicals and subsequent lipid peroxidation have been implicated in the pathogenesis of several degenerative and chronic diseases which are also treated frequently in spas. There are some data arising from previous studies which support an antioxidant or scavenging effect of iodide, being the essential ingredient of a therapeutically used local brine. The aim of the study was to test the antioxidant capacity of iodide in human serum. For this reason we measured the so‐called Total Antioxidant Status determined by a colorimetric method, which reflects the protection against the attack of reactive oxygen species, including enzymic and non‐enzymic antioxidants. Exogenous iodide applied as NaI, shows a significantly increased antioxidant capacity in comparison with NaCl at a concentration of 15 μ m , which is quite comparable to the upper range of serum iodide levels achieved through balneo‐therapeutical intervention. This result is in accordance with previous results from in vitro depolymerization experiments with hyaluronic acid. The antioxidant effect of 15 μ m NaI has been found to be approaching the physiologically relevant concentration of ascorbic acid (50 μ m ). Copyright © 2000 John Wiley & Sons, Ltd.