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Investigation of the effect of theophylline administration on total, free, short‐chain acyl and long‐chain acyl carnitine distributions in rat renal tissues
Author(s) -
Alhomida A. S.
Publication year - 1998
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/(sici)1099-0844(199809)16:3<165::aid-cbf782>3.0.co;2-2
Subject(s) - theophylline , carnitine , endocrinology , medicine , chemistry , kidney , adipose tissue , oral administration
This study is conducted to investigate the effect of oral theophylline administration on total (TC), free (FC), short‐ (SC), long‐chain acyl (LC), acyl (AC) carnitine distributions as well as the ratio of acyl to free carnitine (AC/FC) in rat renal tissues. Theophylline was administrated at 100 mg kg −1 body weight day −1 , and effects were monitored after a treatment period that lasted between 1 week and 5 weeks. The results indicated that theophylline administration leads to significantly higher concentrations of TC, FC, SC, L and AC in renal tissues as compared to those of control and placebo groups ( P <0·001). Moreover, the ratio of AC/FC was significantly increased ( P <0·001) as compared to either control or placebo groups. These changes may result from theophylline‐enhanced mobilization of lipids from adipose tissues, which consequently stimulates an increased carnitine transport into the renal tissues to form acylcarnitines for subsequent β‐oxidation inside the renal mitochondria. © 1998 John Wiley & Sons, Ltd.