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Mechanism of citrinin‐induced dysfunction of mitochondria. VI. Effect on iron‐induced lipid peroxidation of rat liver mitochondria and microsomes
Author(s) -
Ribeiro Sônia M. R.,
Campello Annibal P.,
Chagas Generoso M.,
Klüppel Ma. Lúcia W.
Publication year - 1998
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/(sici)1099-0844(199803)16:1<15::aid-cbf756>3.0.co;2-p
Subject(s) - mitochondrion , citrinin , lipid peroxidation , microsome , chemistry , mechanism (biology) , biochemistry , oxidative stress , enzyme , mycotoxin , food science , philosophy , epistemology
The inhibition by citrinin (CTN) of lipid peroxidation of mitochondria, sub‐mitochondrial particles (SMP) and microsomes was studied. This effect was reversed by the presence of high concentrations of Fe 3+ (0·4 and 0·5 m M ), suggesting chelation of the mycotoxin with iron or interference in the reduction of Fe 3+ . © 1998 John Wiley & Sons, Ltd.