Premium
Nephroprotective effect of betamipron on a new carbapenem, DA‐1131, in rabbits
Author(s) -
Kim So H.,
Kim Won B.,
Kwon Jong W.,
Lee Myung G.
Publication year - 1999
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/(sici)1099-081x(199904)20:3<125::aid-bdd163>3.0.co;2-v
Subject(s) - kidney , renal cortex , pharmacology , renal function , medicine , carbapenem , chemistry , antibiotics , biochemistry
The nephroprotective effect of betamipron (200 mg/kg) was evaluated after intravenous administration of a high dose of DA‐1131 (200 mg/kg) to rabbits. Extensive tubular necrosis was observed without betamipron but the necrosis was not observed with betamipron at 8 h after intravenous administration of DA‐1131 based on kidney microscopy. By treatment with betamipron, the amounts and tissue to plasma (T/P) ratios of DA‐1131 in renal cortex and whole kidney decreased significantly (65–91% decrease) at both 30 min and 2 h after intravenous administration of the drug to rabbits. This indicated that the accumulation of DA‐1131 in rabbit renal cortex and whole kidney was inhibited by betamipron. This resulted in significantly greater percentages of intravenous DA‐1131 excreted in urine as unchanged drug, 60.9 versus 40.1%, and significantly faster renal clearance (Cl r ) of DA‐1131 (6.10 versus 3.22 mL/min/kg) by treatment with betamipron. By treatment with betamipron, the amounts and T/P ratios of DA‐1131 in renal cortex and whole kidney decreased significantly from 30 min and the renal function remained intact at 8 h after intravenous administration of DA‐1131. The above data suggested that the nephroprotective effect of betamipron was fast and persisted for a long period of time in rabbits. Copyright © 1999 John Wiley & Sons, Ltd.