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The influence of food on the disposition of the antiepileptic rufinamide in healthy volunteers
Author(s) -
Cardot J.M.,
Lecaillon J.B.,
Czendlik C.,
Godbillon J.
Publication year - 1998
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/(sici)1099-081x(199805)19:4<259::aid-bdd98>3.0.co;2-v
Subject(s) - cmax , pharmacokinetics , oral administration , anticonvulsant , concomitant , pharmacology , food intake , plasma concentration , area under the curve , medicine , chemistry , epilepsy , psychiatry
The effect of food on the pharmacokinetics of the antiepileptic rufinamide was investigated in healthy volunteers. Twelve subjects were treated with single per‐oral doses of 600 mg of rufinamide after overnight fasting or a fat and protein rich breakfast. Mean (±S.D.) areas under the plasma concentration–time curves (AUCs) of the unchanged compound were 57.2 (16) μg mL −1 h when given to the fasted volunteers and 81.7 (22.2) μg mL −1 h ( p = 0.0001) when given after the breakfast. The average AUC was increased by 44% when rufinamide was given with food and the maximum concentration ( C max ) by about 100%. The time at which C max was reached ( t max ) was shorter (8 h in fasted conditions and 6 h in fed after breakfast); the terminal half‐life was not influenced by concomitant intake of food. © 1998 John Wiley & Sons, Ltd.