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EFFECTS OF FOOD, ANTACID, AND DOSAGE FORM ON THE PHARMACOKINETICS AND RELATIVE BIOAVAILABILITY OF SERTINDOLE IN HEALTHY VOLUNTEERS
Author(s) -
WONG SHEKMAN L.,
LINNEN PAUL,
MACK RANDALL,
GRANNEMAN G. RICHARD
Publication year - 1997
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/(sici)1099-081x(199708)18:6<533::aid-bdd42>3.0.co;2-j
Subject(s) - antacid , bioavailability , sertindole , cmax , pharmacokinetics , bioequivalence , pharmacology , crossover study , dosing , meal , dosage form , chemistry , medicine , food science , placebo , haloperidol , alternative medicine , pathology , dopamine
The pharmacokinetic disposition and relative bioavailability of sertindole administered as a tablet dosage form under fasting conditions, in the presence of food, in the presence of antacid, and as solution was studied in a four‐way crossover in young healthy male volunteers. Overall, tablet dosing after a meal or Maalox had no effect on t 1/2 or AUC values when compared to fasting conditions, but increased the t max and decreased the C max values slightly. The mean relative bioavailabilities of sertindole administered as tablets after fasting, with food, and with Maalox are 99, 104, and 98%, respectively, compared to sertindole solution. Therefore, sertindole can be administered with and without food and without regard to coadministration of antacids. © 1997 John Wiley & Sons, Ltd.