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A COMPUTER PROGRAM USING DISPOSITION DECOMPOSITION ANALYSIS IN PHARMACODYNAMICS
Author(s) -
CHENG HAIYUNG,
GONG YIMING,
JUSKO WILLIAM J.
Publication year - 1997
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/(sici)1099-081x(199701)18:1<9::aid-bdd999>3.0.co;2-4
Subject(s) - pharmacodynamics , drug , distribution (mathematics) , volume of distribution , pharmacokinetics , disposition , chemistry , pharmacology , medicine , mathematics , psychology , mathematical analysis , social psychology
A personal computer based program (DDAPD1) was developed for calculating or determining the apparent distribution function of a drug to a possibly heterogeneous biophase, the mean transit time of a drug at the biophase, the ratio of distribution clearance to biophase volume of distribution, the drug concentration–time function at the biophase ( C b ( t )), and a function which reflects the relationship between the pharmacodynamic response and C b ( t ) of the drug. This program uses an approach based on disposition decomposition analysis and the hysteresis minimization principle. The application of the program is demonstrated using published data for heptabarbital. © 1997 by John Wiley & Sons, Ltd.