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COMPARATIVE ABSORPTION OF BISMUTH IN SPRAGUE–DAWLEY RATS FOLLOWING ORAL ADMINISTRATION OF PREPARATIONS CONTAINING BISMUTH SUCROSE OCTASULFATE, BISMUTH SUBSALICYLATE, AND BISMUTH SUBCITRATE
Author(s) -
RAO NIRANJAN,
BROWN PAUL W.,
YERINO PHYLLIS,
CHANG JIM,
HWANG KINKAI
Publication year - 1997
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/(sici)1099-081x(199701)18:1<1::aid-bdd996>3.0.co;2-0
Subject(s) - bismuth , chemistry , cmax , absorption (acoustics) , oral administration , urine , medicine , chromatography , endocrinology , pharmacokinetics , biochemistry , materials science , organic chemistry , composite material
The absorption of bismuth from De‐Nol (bismuth subcitrate, DN), Pepto‐Bismol (bismuth subsalicylate, PB) and bismuth sucrose octasulfate (BISOS) was examined in male Sprague–Dawley rats after a single oral dose of each compound (60 mg bismuth). Bismuth was analysed in blood, urine, kidney, brain, liver, and lung using graphite furnace atomic absorption spectrophotometry. Bismuth C max averaged 18·4±11·6 ng mL −1 for BISOS, 292±130 ng mL −1 for DN, and 21·5±9·63 ng mL −1 for PB. C max was significantly lower for BISOS compared to DN ( p <0·05) but not significantly different for BISOS compared to PB ( p >0·05). Bismuth AUC was 1356±474 ng h −1 mL −1 for BISOS, 2129−452 ng h −1 mL −1 for DN, and 1824−919 ng h −1 mL −1 for PB, which indicated a lower extent of absorption from BISOS compared to DN. Kidney, liver, and lung levels of bismuth were also significantly lower for BISOS compared to DN ( p <0·05). Bismuth urinary excretion was significantly lower for BISOS (0·04±0·02%) compared to DN (0·27±0·15%) but not significantly different compared to PB (0·07±·03%). These data suggest that the absorption of bismuth following oral administration of bismuth sucrose octasulfate is significantly lower than that from De‐Nol and similar to that from Pepto‐Bismol. © 1997 by John Wiley & Sons, Ltd.