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Development of predictive retention–activity relationship models of antipsychotic drugs by micellar liquid chromatography
Author(s) -
MartínBiosca Y.,
MoleroMonfort M.,
Sagrado S.,
VillanuevaCamañas R. M.,
MedinaHernández M. J.
Publication year - 1999
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/(sici)1099-0801(199911)13:7<478::aid-bmc916>3.0.co;2-v
Subject(s) - chemistry , micellar liquid chromatography , chromatography , metabolite , membrane , biological fluids , micelle , organic chemistry , biochemistry , aqueous solution
The predictive and interpretative capability of quantitative chromatographic retention–biological activity models is supported by the fact that in adequate experimental conditions the solute partitioning into the chromatographic system can emulate the solute partitioning into lipid bilayers of biological membranes, which is the basis of drug and metabolite uptake, passive transport across membranes and bioaocumulation. The use of micellar solutions of Brij35 as mobile phases in reversed liquid chromatography has proven to be valid in predicting some biological activities of different kinds of drugs. In this paper, the correlations between the logarithm of capacity factors and pharmacokinetic, preclinical pharmacology and therapeutic efficacy parameters of phenothiazines are studied. Parabolic quantitative retention–activity relationship models with predictive and interpretative ability have been obtained. Copyright © 1999 John Wiley & Sons, Ltd.