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Enhanced theophylline metabolism in patients with bronchial asthma at age 4 and under
Author(s) -
Kizu Junko,
Arakawa Motoki,
Arakawa Yoshihiro,
Komoda Fusako,
Takamizawa Masaru,
Iwata Tsutomu,
Hayakawa Tetsuo,
Imai Kazuhiro
Publication year - 1999
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/(sici)1099-0801(199911)13:7<462::aid-bmc912>3.0.co;2-p
Subject(s) - theophylline , asthma , chemistry , metabolism , enzyme , drug , drug metabolism , pharmacology , plasma levels , plasma concentration , medicine , biochemistry
Abstract The plasma levels of theophylline (TP) and its metabolites were measured in patients with bronchial asthma who were treated with a slow‐release preparation of TP. The ratios of the plasma levels of these metabolites to TP levels in the group aged 1–4 years were larger than those in the group aged 5 years and older, suggesting enhanced activity of drug‐metabolizing enzymes during infancy. Copyright © 1999 John Wiley & Sons, Ltd.