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Interaction of carbamazepine and chlorpromazine in rabbits
Author(s) -
Rukhadze Marina D.,
Alexishvili Maka M.,
Okujava Vazha M.,
Makharadze Teona G.,
Sebiskveradze Maya V.,
Tsagareli Sonya K.
Publication year - 1999
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/(sici)1099-0801(199911)13:7<445::aid-bmc909>3.0.co;2-z
Subject(s) - chlorpromazine , carbamazepine , chemistry , biotransformation , pharmacology , pharmacokinetics , microsome , gastrointestinal tract , drug metabolism , oral administration , metabolism , enzyme , biochemistry , medicine , psychiatry , epilepsy
The interaction of carbamazepine and chlorpromazine in rabbits has been studied. The drugs were administrated as single oral doses (200 mg of each drug). The sequence of administration of the drugs was varied. It has been established that by simultaneous administration these drugs decrease absorption of each other in plasma. This may be explained by competition of the drugs to transfer from the gastrointestinal tract into plasma, as well as by the formation of complexes, more or less stable and more or less bound to gastrointestinal tissues. Carbamazepine intensifies the biotransformation of chlorpromazine, which may be caused by the ability of carbamazepine to induce microsomal liver enzymes. Chlorpromazine suppresses the biotransformation of carbamazepine, however. This may be caused by intensive capture of chlorpromazine by liver tissues and by its intensive biotransformation, which in turn is conditioned by its surface‐active nature and by the increase of its metabolism with carbamazepine. Therefore the biotransformation of chlorpromazine is increased and metabolism of carbamazepine is reduced. The sequence of administration of the drugs affects their pharmacokinetics significantly. Copyright © 1999 John Wiley & Sons, Ltd.