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Direct enantiomeric resolution of some 2‐arylpropionic acids using (−)‐brucine‐impregnated thin‐layer chromatography
Author(s) -
Bhushan R.,
Thiongo G. Thuku
Publication year - 1999
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/(sici)1099-0801(199906)13:4<276::aid-bmc843>3.0.co;2-m
Subject(s) - chemistry , brucine , chromatography , enantiomer , resolution (logic) , thin layer chromatography , organic chemistry , biochemistry , artificial intelligence , computer science , strychnine
Direct enantioseparation of (±)‐ibuprofen and (±)‐flurbiprofen was achieved by two‐dimensional thin‐layer chromatography on silica gel plates impregnated with optically pure (−)‐brucine as chiral selector. The solvent systems that were successful in resolving both the compounds were acetonitrile–methanol (16:3 v/v) for the first dimension and acetonitrile–methanol–water (16:3:0.4, v/v) for the second dimension. Iodine vapour was used for detection; the detection limit for both (±)‐ibuprofen and (±)‐flurbiprofen was 0.1 µg. Copyright © 1999 John Wiley & Sons, Ltd.