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Colchicine poisoning: report of a fatal case with body fluid and post‐mortem tissue analysis by high‐performance liquid chromatography
Author(s) -
Dehon Betty,
Chag JeanLuc,
Vinner Elisabeth,
Pommery Jean,
Mathieu Daniel,
Lhermitte Michel
Publication year - 1999
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/(sici)1099-0801(199905)13:3<235::aid-bmc827>3.0.co;2-n
Subject(s) - chemistry , colchicine , ingestion , chromatography , high performance liquid chromatography , autopsy , kidney , lung , medicine , biochemistry
A case involving a suicide by the ingestion of colchicine tablets is presented. Liquid chromatography has been used to measure the drug level in blood and in post‐mortem tissues of the patient (a 42‐year‐old man). Plasma concentration 24 h after ingestion was 4.5 ng/mL. On autopsy, the kidney showed the highest concentration (396 ng/g). High concentrations were also found in the liver (347 ng/g) and heart (334 ng/g). Low concentrations were detected in the lung (58 ng/g), muscle (10 ng/g) and brain (5 ng/g). Copyright © 1999 John Wiley & Sons, Ltd.