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A first and straightforward approach to detection limits for narrow‐bore HPLC and CE
Author(s) -
Campaña A. M. García,
Baeyens W. R. G.,
Van der Weken G.,
Rodríguez L. Cuadros,
Barrero F. Alés
Publication year - 1998
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/(sici)1099-0801(199805/06)12:3<177::aid-bmc801>3.0.co;2-v
Subject(s) - chemistry , chromatography , detection limit , calibration , measure (data warehouse) , high performance liquid chromatography , simple (philosophy) , set (abstract data type) , data set , computer science , artificial intelligence , data mining , statistics , mathematics , philosophy , epistemology , programming language
Two methodologies have been proposed for a simple statistical estimation of the detection limits in microbore‐HPLC and CE techniques. Due to the impossibility to measure the blank, by using the extrapolated or approximated expressions it is possible to obtain a straightforward approach of the detection limits from the study of the residuals of the calibration data set, avoiding tedious treatment of the signals. The utility of these expressions has been checked on the data from an experimental microbore HPLC system.