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Metabolism and Bioaccumulation of Fenvalerate and its Metabolites in Rat Organs
Author(s) -
Misra Swati,
Sharma C. B.
Publication year - 1997
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/(sici)1099-0801(199701)11:1<50::aid-bmc625>3.0.co;2-8
Subject(s) - fenvalerate , chemistry , bioaccumulation , metabolism , high performance liquid chromatography , chromatography , metabolite , benzoic acid , pesticide , biochemistry , environmental chemistry , biology , agronomy
Metabolism and bioaccumulation of fenvalerate and its fenvalerate and its metabolites in liver, kidney and brain of rat following the oral administration of a sub‐lethal dose (15 mg/kg) of the pesticide for 7, 15 and 30 day periods was investigated by high‐performance liquid chromatography (HPLC) in terms of the relative mole concentrations in rat tissues. The cleavage of the ester linkage in fenvalerate yielding two metabolites was found to be the primary step in the biodegradation of fenvalerate in rat organs. These metabolites were purified to homogeneity by HPLC and characterized by infra‐red spectroscopy as 4‐chloro‐α‐(1‐methylethyl) benzeneacetic acid and 3‐phenoxy benzoic acid. © 1997 by John Wiley & Sons, Ltd.