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Comparison of High Performance Capillary Electrophoresis and Liquid Chromatography for the Determination of Acyclovir and Guanine in Pharmaceuticals and Urine
Author(s) -
Zhang S. S.,
Liu H. X.,
Chen Y.,
Yuan Z. B.
Publication year - 1996
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/(sici)1099-0801(199609)10:5<256::aid-bmc600>3.0.co;2-c
Subject(s) - chemistry , chromatography , capillary electrophoresis , urine , high performance liquid chromatography , reproducibility , guanine , biochemistry , nucleotide , gene
High‐performance capillary electrophoresis (HPCE) and high‐performance liquid chromatography (HPLC) were developed and applied to the determination of acyclovir (ACV) and guanine (G) in pharmaceuticals. The comparison study showed that two methods gave comparable results in linear range, recovery and reproducibility. HPCE was used for the determination of ACV and G in urine; the recovery was better than 81.3% and the RSD was less than 4.4%.