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Effect of temperature on the high‐performance liquid chromatographic separation of the anti‐HIV agents, didanosine and stavudine
Author(s) -
Stancato Frank A.,
Srinivas Nuggehally R.,
Knupp Catherine A.
Publication year - 1996
Publication title -
biomedical chromatography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.4
H-Index - 65
eISSN - 1099-0801
pISSN - 0269-3879
DOI - 10.1002/(sici)1099-0801(199601)10:1<29::aid-bmc543>3.0.co;2-w
Subject(s) - stavudine , didanosine , chemistry , chromatography , chromatographic separation , human immunodeficiency virus (hiv) , zidovudine , virology , high performance liquid chromatography , medicine , viral disease
This paper examines the effect of temperature on the chromatographic separation characteristics of anti‐HIV agents, didanosine and stavudine. As a result of lowering the column temperature, an improved resolution between didanosine and stavudine peaks is observed. Thus, lower temperatures may permit the simultaneous monitoring of didanosine and stavudine levels.