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Neurotropic and antitumor activities of silyl‐ and germyl‐isoxazolin‐2‐yl derivatives
Author(s) -
Lukevics E.,
Arsenyan P.,
Germane S.,
Shestakova I.
Publication year - 1999
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/(sici)1099-0739(199910)13:10<795::aid-aoc909>3.0.co;2-v
Subject(s) - chemistry , silylation , alkyl , stereochemistry , organic chemistry , catalysis
Neurotropic and antitumor activities of the pyridyl‐substituted 5‐Si(Ge)‐isoxazolines and (3‐alkyl‐4‐triphenylgermylisoxazolin‐2‐yl)‐5‐carboxylic acid ethyl esters have been investigated. It has been shown that silylisoxazolin‐2‐yl derivatives are more potent in protection against hypoxia and Corazole convulsions than their analogues. Germylisoxazolin‐2‐yl compounds are stronger tumor growth inhibitors and NO‐inducers than their silyl analogues. Copyright © 1999 John Wiley & Sons, Ltd.