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Multiple mechanisms for cytotoxicity induced by copper(II) complexes of 2‐acetylpyrazine‐ N ‐substituted thiosemicarbazones
Author(s) -
Miller M. C.,
Stineman C. N.,
Vance J. R.,
West D. X.,
Hall I. H.
Publication year - 1999
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/(sici)1099-0739(199901)13:1<9::aid-aoc818>3.0.co;2-#
Subject(s) - chemistry , cytotoxicity , copper , semicarbazone , stereochemistry , combinatorial chemistry , organic chemistry , in vitro , biochemistry
The purpose of this study was to evaluate the mechanism by which 2‐acetylpyrazine‐ 4 N ‐substituted thiosemicarbazone copper II complexes mediate their cytotoxicity. These compounds were shown to be cytotoxic to a variety of human and rodent tumors in cell culture and are potent cytocidal agents as determined by dilute agar colony assays. They demonstrated the ability to inhibit several enzymes in vitro including DNA topoisomerase II activity. The data presented suggest that cytotoxicity may be mediated by the cumulative effect of several enzymes being inhibited by the agents. Copyright © 1999 John Wiley & Sons, Ltd.