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Synthesis of radioactive tributyl[ 113 Sn]tin of high specific activity for use in environmental fate studies
Author(s) -
Rouleau Claude
Publication year - 1998
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/(sici)1099-0739(199806)12:6<435::aid-aoc717>3.0.co;2-n
Subject(s) - chemistry , tin , yield (engineering) , tributyl phosphate , chloride , aqueous solution , nuclear chemistry , extraction (chemistry) , radiochemistry , environmental chemistry , organic chemistry , metallurgy , materials science
A method of synthesis of tributyl[ 113 Sn]tin,(n/C 4 H 9 ) 3 113 Sn(IV), from commercially avail‐able inorganic 113 Sn(IV) is presented. Inorganic tin is first extracted in diethyl ether and reacted with C 4 H 9 MgCl to produce tetrabutyltin, (C 4 H 9 ) 4 113 Sn, which is then debutylated with HgCl 2 . The resulting tributyl[ 113 Sn]tin chloride is isolated from the reaction mixture by successive extractions with hexane and aqueous Na 2 S 2 O 3 . The yield is 40–60% and the product obtained is >98% pure. It has the same specific activity as the starting 113 Sn(IV), i.e. up to 550 MBq mg −1 Sn, making it suitable for use in environmental fate and toxicology studies at concentrations relevant of those found in the aquatic environment. © 1998 John Wiley & Sons, Ltd.