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Bioactive versatile azomethine complexes of organotin(IV) and organosilicon(IV)
Author(s) -
Belwal Savita,
Singh R. V.
Publication year - 1998
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/(sici)1099-0739(199801)12:1<39::aid-aoc669>3.0.co;2-g
Subject(s) - organosilicon , chemistry , semicarbazone , antimicrobial , ligand (biochemistry) , carbon 13 nmr , elemental analysis , nuclear chemistry , stereochemistry , in vitro , medicinal chemistry , organic chemistry , polymer chemistry , biochemistry , receptor
Diorganotin(IV) and diorganosilicon(IV) derivatives of the types R 2 MCl(TSCZ) and R 2 M(TSCZ) 2 (where TSCZ is the anion of a thiosemicarbazone ligand, R=Ph or Me and M=Sn or Si) have been synthesized and characterized by elemental analyses, molecular weight determinations and conductivity measurements. The mode of bonding has been established on the basis of IR and 1 H, 13 C 29 Si and 119 Sn NMR spectroscopic studies. Some of the representative complexes have also been evaluated for their antimicrobial effects on different species of pathogenic fungi and bacteria in vivo as well as in vitro. The results of these investigations are reported. © 1998 John Wiley & Sons, Ltd.