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Synthesis, characterization and cytotoxic activity of complexes of diorganotin(IV) halides with N ‐methyl‐2,2′‐bisimidazole
Author(s) -
Boo P. Alvarez,
Casas J. S.,
Couce M. D.,
Freijanes E.,
Furlani A.,
Scarcia V.,
Sordo J.,
Russo U.,
Varela M.
Publication year - 1997
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/(sici)1099-0739(199712)11:12<963::aid-aoc656>3.0.co;2-6
Subject(s) - chemistry , denticity , adduct , acetonitrile , raman spectroscopy , octahedron , ligand (biochemistry) , halide , stereochemistry , mössbauer spectroscopy , nuclear magnetic resonance spectroscopy , medicinal chemistry , solvent , crystallography , inorganic chemistry , crystal structure , organic chemistry , receptor , biochemistry , physics , optics
The compounds [SnR 2 X 2 (MBIm)] (MBIm= N ‐methyl‐2,2′‐bisimidazole; R=Me, Et, Bu, Ph; X=Cl or Br) have been synthesized and characterized by IR, Raman, Mössbauer and NMR spectroscopy, and their capacity to inhibit tumour cell division has been assayed. Measurements of conductivity in acetonitrile show the adducts to behave as non‐ionogens in this solvent. The IR, Raman and Mössbauer data suggest that all the complexes have analogous pseudo‐octahedral coordination geometries, with the R groups trans and MBIm bidentate. The 1 H NMR spectra show the MBIm ligand to be partially dissociated in CDCl 3 . The most active compounds against the established cell line KB were the butyl derivatives. © 1997 John Wiley & Sons, Ltd.