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Relationship between Hemolytic Toxicity and Signal Intensity of Various Organotin Compounds by a Spin‐labeling Technique
Author(s) -
Sato Takahiko,
Masumoto Hideki,
Nagase Hisamitsu,
Kito Hideaki,
Niikawa Miki
Publication year - 1997
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/(sici)1099-0739(199703)11:3<231::aid-aoc556>3.0.co;2-p
Subject(s) - chemistry , hemolysis , stearic acid , electron paramagnetic resonance , toxicity , spin probe , alkyl , site directed spin labeling , intensity (physics) , nuclear magnetic resonance , organic chemistry , physics , immunology , biology , quantum mechanics
Abstract Various organotin compounds caused strong hemolysis of erythrocytes. To investigate the mechanism of hemolysis, spin‐labeling techniques with electron spin resonance (ESR) spectroscopy were used and the relationship between hemolytic toxicity and signal intensity was investigated. Two kinds of spin‐labeled stearic acid in which the para‐ magnetic center was located at different sites on the alkyl chain (5‐ and 12‐doxyl‐stearic acids; 5‐ and 12‐NS) were used. It became clear that the decrease of ESR signal intensity was related to the hemolytic toxicity of the organotin compounds. © 1997 by John Wiley & Sons, Ltd.