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The Anti‐inflammatory Activiy of Metal Complexes of Heterocyclic Thiosemicarbazones, 2‐Substituted Pyridine N ‐Oxides and 2‐Pyridylthioureas
Author(s) -
Hall Iris H.,
Chen S. Y.,
Rajendran K. G.,
West D. X.
Publication year - 1996
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/(sici)1099-0739(199609)10:7<485::aid-aoc504>3.0.co;2-#
Subject(s) - chemistry , tumor necrosis factor alpha , leukotriene b4 , pharmacology , carrageenan , enzyme , inflammation , anti inflammatory , lipoxygenase , prostaglandin , biochemistry , immunology , medicine , biology
The thiosemicarbazones and their related metal complexes were shown to be potent anti‐inflammatory agents in rodents at 8 mg kg −1 . They were effective in blocking induced edema and endotoxic shock while blocking both local and central pain processes. The ability of the agents to function as anti‐inflammatory agents is multifold. First, Tumor Necrosis Factor‐alpha (TNFα) and Interleukin‐1 (IL‐1) release was markedly reduced by the agents. Second, high‐affinity receptor binding on fibroblasts of TNFα and IL‐1 was significantly inhibited. Third, cellular events, e.g. lysosomal enzymes of specific cells, such as macrophages, were inhibited and prostaglandin cyclo‐oxygenase and leukotriene 5′‐lipoxygenase enzymic synthetic rates were significantly reduced, which should cause an overall reduction of the inflammatory process.