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Synthesis of Trimethylamine‐[ 14 C]carboxyborane and Trimethylamine‐[ 14 C]carboxymethoxyborane and L1210 Leukemia Cell Uptake
Author(s) -
Chen S. Y.,
Burnham Bruce S.,
Spielvogel Bernard F.,
Sood A.,
Wyrick Steven D.,
Hall Iris H.
Publication year - 1996
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/(sici)1099-0739(199604)10:3/4<279::aid-aoc470>3.0.co;2-8
Subject(s) - trimethylamine , chemistry , l1210 cells , leukemia , dna , biochemistry , cell , combinatorial chemistry , stereochemistry , cytotoxicity , in vitro , immunology , biology
The anti‐neoplastic agents trimethylamine‐carboxyborane and its corresponding methyl ester have successfully been radiolabeled with carbon‐14 in the carboxyl group. Using the radiolabeled agents we have shown that their L1210 leukemia cell uptake appeared to be by a passive process and binding of the agents to DNA, RNA and protein over 24 h was minimal.