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New Germaheterocycles, Germadithioacetals and a Germylated Oxide and Sulfide Derived from Cysteamine, Methylcysteamine and N ‐Substituted Cysteamine: Synthesis and Radioprotective Activity
Author(s) -
Rima G.,
Satgé J.,
SentenacRoumanou H.,
Fatome M.,
Laval J. D.,
Lion C.,
Dagiral R.
Publication year - 1996
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/(sici)1099-0739(199603)10:2<113::aid-aoc486>3.0.co;2-v
Subject(s) - cysteamine , chemistry , toxicity , sulfide , pharmacology , biochemistry , organic chemistry , medicine
Further to our work concerning organometallic compounds active in chemical radioprotection, we report the synthesis and pharmacological study (radioprotective activity, toxicity) of new germathiazolidines and germadithioacetals derived from cysteamine, methylcysteamine and N ‐substituted cysteamine. A germylated oxide and sulfide with methylcysteamine hydrochloride as ligand were also investigated. A notable decrease in the toxicity and a fairly large increase in the radioprotective activity of these new organogermylated compounds were observed compared with cysteamine, methylcysteamine and N ‐substituted cysteamine.