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Synthesis, characterization and cytotoxic activity of diorganotin (IV) complexes with 4 H ‐pyrido[1,2‐ a ]pyrimidin‐4‐one derivatives
Author(s) -
AlAllaf Talal A.K.,
AlBayati Redha I.H.,
Rashan Luay J.,
Khuzaie Rula F.
Publication year - 1996
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/(sici)1099-0739(199602)10:1<47::aid-aoc476>3.0.co;2-3
Subject(s) - chemistry , nitrogen atom , steric effects , denticity , tin , stereochemistry , pyrimidine , derivative (finance) , medicinal chemistry , crystallography , group (periodic table) , crystal structure , organic chemistry , financial economics , economics
The coordination behaviour of the diorganotin (IV) compounds R 2 SnCl 2 (where R = Me, Ph) with 4 H ‐pyrido [1,2‐ a ] pyrimidin‐4‐one derivatives (L) has been described. The complexes R 2 SnCl 2 · L obtained have been characterized physicochemically and spectroscopically. The pyrimidin‐4‐one ligands were found to coordinate with R 2 SnCl 2 species in a monodentate fashion, mainly via the oxygen atom of the 4‐one group or possibly via the nitrogen atom of the (SINGLE BOND)C(DOUBLE BOND)N linkage (the less sterically hindered nitrogen of the pyrimidine derivative) to give pentacoordinate tin complexes. Of the complexes selected to be screened against five tumour cell lines, some exhibited significant in vitro activity.