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A Simple Polyheterotopic Molecular Receptor Derived from Bispyrazolylmethane Showing Ambivalent Allosteric Cooperation of Zinc(II)
Author(s) -
Brunet Ernesto,
Juanes Olga,
Mata María José de la,
RodríguezUbis Juan C.
Publication year - 2000
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/(sici)1099-0690(200005)2000:10<1913::aid-ejoc1913>3.0.co;2-y
Subject(s) - chemistry , allosteric regulation , pyrazole , zinc , ammonium , metal , simple (philosophy) , stereochemistry , crystallography , computational chemistry , inorganic chemistry , receptor , organic chemistry , biochemistry , philosophy , epistemology
The preparation of compounds 1–4 as simple systems to display allostery is described. Transport experiments (bulk liquid membrane) of ammonium cations in the presence or absence of ZnI 2 in the receiving and donor phases evidenced strong negative or positive allosteric effects of the metal towards ammonium complexation, which depended on the relative arrangement of crowns with respect to the pyrazole nitrogens.