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Azeotropic Transesterification of β‐Keto Esters
Author(s) -
Christoffers Jens,
Önal Neclâ
Publication year - 2000
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/(sici)1099-0690(200004)2000:8<1633::aid-ejoc1633>3.0.co;2-w
Subject(s) - chemistry , azeotrope , transesterification , organic chemistry , cyclohexane , boiling , stoichiometry , dehydrogenation , catalysis , distillation
Transesterifications of methyl β‐keto carboxylates catalyzed by DMAP with various high boiling alcohols can be accomplished in refluxing cyclohexane in a Dean‐Stark trap. The MeOH formed is removed completely from the reaction mixture as an azeotrope leading to quantitative conversions. The starting materials are converted in stoichiometric ratio, which makes the purification of the product very simple and results in high yields.