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Synthesis of 10β,17α‐Dimethyl‐17β‐(1,2‐dioxopropyl)estra‐5,9‐diene‐3‐ketal
Author(s) -
Gertosio Valérie,
Santini Catherine C.,
Basset JeanMarie,
Bayard François,
Vivat Michel,
Buendia Jean
Publication year - 2000
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/(sici)1099-0690(200004)2000:8<1521::aid-ejoc1521>3.0.co;2-f
Subject(s) - chemistry , sterol , diene , steroid , fermentation , organic chemistry , stereochemistry , biochemistry , cholesterol , natural rubber , hormone
The synthesis of a new progestomimetic steroid, analogous to the cetaloxopromegestone precursor of Trimegestone has been carried out in eight steps from 9α‐hydroxyandrost‐4‐ene‐3,17‐dione. This latter compound can be obtained from the fermentation of γ‐sitosterol, a sterol extracted from soya bean oil.