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Oxidative Heterocyclization of 2‐Alkynylbenzaldehydes with 1,2‐Phenylenediamine
Author(s) -
Dyker Gerald,
Stirner Wolfgang,
Henkel Gerald
Publication year - 2000
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/(sici)1099-0690(200004)2000:8<1433::aid-ejoc1433>3.0.co;2-7
Subject(s) - chemistry , oxidative phosphorylation , nitrobenzene , alkyne , condensation , medicinal chemistry , p phenylenediamine , organic chemistry , catalysis , biochemistry , physics , thermodynamics
Upon condensation of ortho ‐phenylenediamine ( 2 ) with ortho ‐alkynylbenzaldehydes in nitrobenzene, oxidative cyclizations are observed, which result in benzimidazo[2,1‐ a ]isoquinolines (8) or isoindolo[2,1‐ a ]quinoxalines (9) depending on the influence of additional substituents at the alkyne.