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Remote Anisotropic Effects in Diastereomeric Esters of Fluorinated O ‐Aryllactic Acids
Author(s) -
Gras JeanLouis,
Soto Thierry,
Heumann Andreas
Publication year - 2000
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/(sici)1099-0690(200003)2000:5<837::aid-ejoc837>3.0.co;2-2
Subject(s) - diastereomer , chemistry , enantiomer , chiral derivatizing agent , stereochemistry , anisotropy , organic chemistry , chiral column chromatography , physics , quantum mechanics
The enantiomeric purity of a chiral compound is determined by NMR spectroscopic analysis of the diastereomers formed with a chiral derivatizing agent. Fluorinated O ‐aryllactic acids (FAC) 1 are efficient chiral reporters, whose spectacular remote anisotropic effects allow an easy identification and measurement of diastereomers. The remote effects are attributed to the particular design of FAC esters relative to other CDAs.