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A Radical‐Based Strategy for the Synthesis of Higher Homologues of Sinefungin
Author(s) -
José Maria Edmilson,
da Silva Adilson David,
Fourrey JeanLouis
Publication year - 2000
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/(sici)1099-0690(200002)2000:4<627::aid-ejoc627>3.0.co;2-i
Subject(s) - chemistry , iodide , radical cyclization , sequence (biology) , combinatorial chemistry , zinc , copper , stereochemistry , organic chemistry , biochemistry
Homosinefungin 5 , which can be considered as an analogue of S ‐adenosylmethionine (SAM) and of S ‐adenosylhomocysteine (SAH), has been synthesized by means of a sequence in which the key step was the addition of a radical, produced by the simple treatment of an iodide precursor with a zinc‐copper couple, to suitably activated olefins.