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New Strategies for an Efficient Removal of the 9‐Fluorenylmethoxycarbonyl (Fmoc) Protecting Group in the Peptide Synthesis
Author(s) -
Leggio Antonella,
Liguori Angelo,
Napoli Anna,
Siciliano Carlo,
Sindona Giovanni
Publication year - 2000
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/(sici)1099-0690(200002)2000:4<573::aid-ejoc573>3.0.co;2-i
Subject(s) - chemistry , protecting group , reagent , combinatorial chemistry , peptide , peptide synthesis , toluene , organic chemistry , biochemistry , alkyl
The aluminium trichloride/toluene system is investigated as a novel, unusual and straightforward reagent for the removal of the 9‐fluorenylmethoxycarbonyl (Fmoc) protecting group in the solution peptide synthesis. This procedure avoids any undesired side reactions, such as the frequently observed inversion of the amino acid configuration.