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The S ‐Thioester Enolate/Imine Condensation: A Shortcut to β‐Lactams
Author(s) -
Benaglia Maurizio,
Cinquini Mauro,
Cozzi Franco
Publication year - 2000
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/(sici)1099-0690(200002)2000:4<563::aid-ejoc563>3.0.co;2-m
Subject(s) - thioester , chemistry , imine , condensation , condensation reaction , combinatorial chemistry , aldol condensation , enantioselective synthesis , stereochemistry , organic chemistry , computational chemistry , catalysis , physics , thermodynamics , enzyme
The condensation between imines and S‐ thioester metal enolates provides a mild, efficient, and straightforward route to the preparation of β‐lactams. The synthetic applications and the stereochemical aspects of this reaction are discussed.