Premium
New Methodologies Based on Arene‐Catalyzed Lithiation Reactions and Their Application to Synthetic Organic Chemistry
Author(s) -
Ramón Diego J.,
Yus Miguel
Publication year - 2000
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/(sici)1099-0690(200001)2000:2<225::aid-ejoc225>3.0.co;2-a
Subject(s) - chemistry , catalysis , organic chemistry , stoichiometry , organic synthesis , combinatorial chemistry , organolithium compounds , ion , deprotonation
The applications of arene‐catalyzed lithiation reactions during recent years are reviewed. This methodology has been used to obtain functionalized organolithium compounds from halogenated as well as nonhalogenated materials, such as heterocycles, sulfones, triflates, ethers, thioethers, amides, and esters. This arene‐catalyzed lithiation has also been used in the preparation of polylithiated intermediates. Sub‐stoichiometric amounts of the arene may be supported on a polymeric material, its catalytic activity being as efficient as in the solution version.