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Palladium‐Catalyzed Hydrovinylation of Vinyl Triflates with Alkynes An Approach to the Synthesis of 3‐Vinylfuran‐2(5 H )‐ones
Author(s) -
Arcadi Antonio,
Cacchi Sandro,
Fabrizi Giancarlo,
Marinelli Fabio,
Pace Paola
Publication year - 1999
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/(sici)1099-0690(199912)1999:12<3305::aid-ejoc3305>3.0.co;2-o
Subject(s) - chemistry , regioselectivity , catalysis , palladium , reaction conditions , organic chemistry , combinatorial chemistry
The reaction of alkynes with vinyl triflates in the presence of catalytic amounts of Pd(OAc) 2 and HCOOK, omitting phosphane ligands, affords hydrovinylation products usually in good to high yields. The reaction has been employed to develop a regioselective synthesis of 3‐vinylfuran‐2(5 H )‐ones from methyl 4‐hydroxy‐2‐butynoates.