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A Convenient Synthetic Route to Polyether‐Tagged Cyclam Ligands andTheir Nickel Derivatives
Author(s) -
Bellouard Frédéric,
Chuburu Françoise,
Yaouanc JeanJaques,
Handel Henri,
Le Mest Yves
Publication year - 1999
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/(sici)1099-0690(199912)1999:12<3257::aid-ejoc3257>3.0.co;2-8
Subject(s) - cyclam , chemistry , nickel , reactivity (psychology) , stabiliser , electrochemistry , polyethylene oxide , polymer chemistry , combinatorial chemistry , organic chemistry , polymer , metal , electrode , food science , medicine , alternative medicine , pathology
A specific strategy is described for the synthesis of stable polyethylene oxide tagged tetraazamacrocycles (PEO‐cyclam) in five steps (overall yields for 12 and 13 48% and 22%, respectively). Various attempts via classical pathways demonstrated: (i) the low reactivity of PEO derivatives, and (ii) the necessity of a stabiliser arm between the cyclam and the PEO chain. Nickel complexes have been prepared and characterised by electrochemistry.