Premium
Structure of Neuritogenic Active Ganglioside from the Sea Cucumber Stichopus japonicus
Author(s) -
Kaneko Masafumi,
Kisa Fumiaki,
Yamada Koji,
Miyamoto Tomofumi,
Higuchi Ryuichi
Publication year - 1999
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/(sici)1099-0690(199911)1999:11<3171::aid-ejoc3171>3.0.co;2-b
Subject(s) - chemistry , ganglioside , ceramide , stereochemistry , sialic acid , chloroform , biochemistry , sphingolipid , glycolipid , methanol , organic chemistry , apoptosis
Abstract A ganglioside molecular species SJG‐1 has been obtained from the n ‐hexane soluble lipid fraction of the chloroform/methanol extract of the sea cucumber Stichopus japonicus . On the basis of chemical and spectroscopic evidence, the structure of SJG‐1 has been determined. SJG‐1 possesses an N ‐glycolylneuraminic acid (sialic acid), nonhydroxy fatty acids and phytosphingosine‐type long‐chain bases as major ceramide components. The ganglioside SJG‐1 exhibits neuritogenic activity toward the rat pheochromocytoma cell line PC12 cells in the presence of NGF.