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Induced Fit Selection of a Barbiturate Receptor from a Dynamic Structural and Conformational/Configurational Library
Author(s) -
Berl Volker,
Huc Ivan,
Lehn JeanMarie,
DeCian André,
Fischer Jean
Publication year - 1999
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/(sici)1099-0690(199911)1999:11<3089::aid-ejoc3089>3.0.co;2-4
Subject(s) - chemistry , barbiturate , complementarity (molecular biology) , hydrazone , supramolecular chemistry , stereochemistry , combinatorial chemistry , crystallography , crystal structure , psychology , psychiatry , genetics , biology
The selection of the receptor presenting the strongest affinity for a barbiturate substrate from a dynamic combinatorial library of constituents differing in structure and conformation/configuration is described. The gradual addition of the barbiturate to an equilibrating mixture of hydrazone isomers leads to the quantitative shift towards a single species, 3 , which presents highest complementarity to the substrate and yields the supramolecular entity 3:4 .