Premium
Diastereoselective Synthesis of a Precursor of Homocarbocyclic Nucleosides
Author(s) -
GonzalezAlvarez Carmen M.,
Quintero Leticia,
Santiesteban Fernando,
Fourrey JeanLouis
Publication year - 1999
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/(sici)1099-0690(199911)1999:11<3085::aid-ejoc3085>3.0.co;2-s
Subject(s) - chemistry , dihydroxylation , stereospecificity , hydrazine (antidepressant) , derivative (finance) , stereochemistry , combinatorial chemistry , organic chemistry , enantioselective synthesis , catalysis , biochemistry , financial economics , economics
A convenient diastereoselective synthesis of an immediate precursor for a rapid access to a variety of homo‐carbocyclic nucleosides, is described. The synthetic scheme involves a high yielding new type of Pd(0) catalyzed cyclization of a suitable hydrazine derivative together with a stereospecific OsO 4 triggered dihydroxylation step.