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Tin‐ and Indium‐Mediated Allylation Reactions in Water: Highly Stereoselective Synthesis of β‐Trifluoromethylated Homoallylic Alcohols
Author(s) -
Loh TeckPeng,
Li XuRan
Publication year - 1999
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/(sici)1099-0690(199908)1999:8<1893::aid-ejoc1893>3.0.co;2-3
Subject(s) - chemistry , stereoselectivity , tin , organic chemistry , indium , combinatorial chemistry , catalysis
The indium‐mediated allylation reaction of aldehydes with 4‐bromo‐1,1,1‐trifluoro‐2‐butene in water afforded β‐trifluoromethylated homoallylic alcohols in high yields. In most cases, high regio‐ and excellent diastereoselectivities were obtained.