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A New Strategy for the Asymmetric Synthesis of 1,3‐Oxathiolane‐Based Nucleoside Analogues
Author(s) -
Caputo Romualdo,
Guaragna Annalisa,
Palumbo Giovanni,
Pedatella Silvana
Publication year - 1999
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/(sici)1099-0690(199906)1999:6<1455::aid-ejoc1455>3.0.co;2-v
Subject(s) - chemistry , nucleoside , enantiomer , yield (engineering) , stereochemistry , combinatorial chemistry , enantioselective synthesis , organic chemistry , catalysis , materials science , metallurgy
A ready asymmetric synthesis of 3′‐oxathionucleosides has been accomplished in three main steps from benzoyloxyethanal. The synthesis is characterized by high overall yield and considerable enantiomeric excesses. It represents a general synthetic path to prepare a wide range of heterosubstituted sulfur‐containing nucleoside analogues.