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Isolation and Structure of a GM 3 ‐Type Ganglioside Molecular Species
Author(s) -
Kawatake Satoshi,
Inagaki Masanori,
Miyamoto Tomofumi,
Isobe Ryuichi,
Higuchi Ryuichi
Publication year - 1999
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/(sici)1099-0690(199904)1999:4<765::aid-ejoc765>3.0.co;2-7
Subject(s) - starfish , ganglioside , chemistry , stereochemistry , biochemistry , chloroform , chemical structure , chromatography , organic chemistry , biology , ecology
A ganglioside molecular species, LMG‐2 ( 1 ), has been obtained from the water‐soluble lipid fraction of the chloroform/methanol extract of the starfish Luidia maculata . On the basis of chemical and spectroscopic findings, the structure of 1 has been elucidated. 1 is a ganglioside molecular species of starfish resembling the mammalian ganglioside GM 3 . In addition, 1 shows neuritogenic activity toward the rat pheochromocytoma cell line PC‐12 cell.