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A Unified Synthetic Strategy for the Indolopyridine Alkaloid Group
Author(s) -
Lavilla Rodolfo,
Gullón Francisco,
Bosch Joan
Publication year - 1999
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/(sici)1099-0690(199902)1999:2<373::aid-ejoc373>3.0.co;2-z
Subject(s) - chemistry , regioselectivity , derivative (finance) , alkaloid , yield (engineering) , total synthesis , palladium , chloride , stereochemistry , group (periodic table) , combinatorial chemistry , organic chemistry , catalysis , materials science , financial economics , economics , metallurgy
Thermal or acetyl chloride induced cyclization of bromoenamide 10 affords the pentacyclic derivative 12 with high yield and regioselectivity. From this common synthetic intermediate, palladium‐catalyzed reactions allow the total synthesis of indolopyridine alkaloids 1 – 6 .