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Synthesis of Cephalostatin Analogues by Symmetrical and Non‐Symmetrical Routes
Author(s) -
Drögemüller Michael,
Flessner Timo,
Jautelat Rolf,
Scholz Ulrich,
Winterfeldt Ekkehard
Publication year - 1998
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/(sici)1099-0690(199812)1998:12<2811::aid-ejoc2811>3.0.co;2-m
Subject(s) - chemistry , diketone , coupling (piping) , transformation (genetics) , stereochemistry , combinatorial chemistry , organic chemistry , mechanical engineering , biochemistry , engineering , gene
The synthesis of the cephalostatin‐analogous bis‐steroidal pyrazines 6 , 27a/b and 41 by the transformation of the C 2 ‐symmetrical diketone 6 as a central precursor, as well as the direct preparation of several non‐symmetrical bis‐steroidal pyrazines by coupling of enamino ketones ( 5 , 40 ) with vinyl azides ( 17a/b ) is reported. Furthermore, an improved procedure for preparation of the diketone 6 described earlier is presented.