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Isolation and Structure of Biologically Active Gangliosides from the Sea Cucumber Holothuria pervicax
Author(s) -
Yamada Koji,
Harada Yasuo,
Nagaregawa Yoshiteru,
Miyamoto Tomofumi,
Isobe Ryuichi,
Higuchi Ryuichi
Publication year - 1998
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/(sici)1099-0690(199811)1998:11<2519::aid-ejoc2519>3.0.co;2-v
Subject(s) - chemistry , ganglioside , stereochemistry , biochemistry , chemical structure , organic chemistry
Three ganglioside molecular species, HPG‐8 , HPG‐3 , and HPG‐1 , have been obtained from the polar fraction of the chloroform/methanol extract of the sea cucumber Holothuria pervicax . The structures of these gangliosides have been determined on the basis of chemical and spectroscopic evidence. They represent new ganglioside molecular species. HPG‐8 is a sulfated monosialo‐ganglioside, while HPG‐3 and HPG‐1 are disialo‐gangliosides possessing 2→4‐linked tandem‐type disialosyl moieties. These three gangliosides qualitative neuritogenic activity toward the rat pheochromocytoma cell line, PC‐12 cells.