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Structure of the Dimers Obtained From the Reduction of 1‐Benzyl‐3,5‐bis(dialkylcarbamoyl)pyridinium Ions – Models of NAD +
Author(s) -
Leprêtre JeanClaude,
Limosin Danièle,
Pierre Gérard,
Chautemps Pierre,
Pierre JeanLouis
Publication year - 1998
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/(sici)1099-0690(199810)1998:10<2237::aid-ejoc2237>3.0.co;2-m
Subject(s) - conformational isomerism , chemistry , pyridinium , ion , nad+ kinase , stereochemistry , aqueous solution , computational chemistry , crystallography , medicinal chemistry , organic chemistry , molecule , enzyme
In aqueous media the one‐electron reduction of the title compounds on a mercury pool generally gives rise to three dimers, which are distinguishable by HPL chromatography. From spectroscopic analyses it has been possible to propose a structure for these conformers and their stability has been studied. Two conformers are unstable, yielding the third conformer. A mechanism is proposed for this transformation.