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A General Route to the Monomeric Subunits of the Macrotetrolides – A Short Synthesis of Methyl Nonactate
Author(s) -
Meiners Uta,
Cramer Eva,
Fröhlich Roland,
Wibbeling Birgit,
Metz Peter
Publication year - 1998
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/(sici)1099-0690(199810)1998:10<2073::aid-ejoc2073>3.0.co;2-d
Subject(s) - chemistry , monomer , tandem , stereoselectivity , furan , stereochemistry , combinatorial chemistry , organic chemistry , catalysis , polymer , materials science , composite material
A highly stereoselective and flexible sultone route to actic acids, the monomeric subunits of the macrotetrolides, has been developed and exemplified for nonactic acid ( 2a ). Due to the extensive application of tandem transformations, only six steps were needed to secure methyl nonactate ( 20 ) from furan.