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A New Iron‐Mediated Strategy for the Synthesis of α‐Lipoic Acid and Analogues
Author(s) -
Crévisy Christophe,
Herbage Benjamin,
Marrel MarieLaure,
Toupet Loïc,
Grée René
Publication year - 1998
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/(sici)1099-0690(199809)1998:9<1949::aid-ejoc1949>3.0.co;2-8
Subject(s) - chemistry , lipoic acid , diene , combinatorial chemistry , stereochemistry , organic chemistry , antioxidant , natural rubber
Dithioester 10 was synthesized in 6 steps from tricarbonyl(diene)iron complex 3 . Compound 10 is not only a key intermediate for the synthesis of methyl lipoate ( 13 ) but could also be of interest for the preparation of various labelled compounds and structural analogues.